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KMID : 1134820210500121265
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Journal of the Korean Society of Food Science and Nutrition
2021 Volume.50 No. 12 p.1265 ~ p.1274
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Alcoholic Hepatotoxicity Inhibitory Effect Using Heat-Killed Lactic Acid Bacteria
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Chae Hyo-Seok
Cho Hyang-Hyun
Song Woo-Seung
Hwang Kwon-tack
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Abstract
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The purpose of this study was to examine the effects of heat-killed lactic acid bacteria on acute alcoholic liver disease and alcoholic hangover. Histologic analysis exhibited no change except in the ethanol-treated group, but the EtOH＋heat-killed Lactobacillus plantarum high dose-treated group (P<0.01) showed a significant change in the fatty granules in hepatocytes. Similarly, the positive control group (P<0.01) and the EtOH＋HLPH (heat-killed L. plantarum high dose) group (P<0.05) showed significant difference in the hepatic telangiectasis score. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were significantly decreased in the EtOH＋HLPH group (P<0.001 and P<0.01 respectively). Inhibition of inflammation was assessed through cytokine expression. IL-1β mRNA expression was significantly inhibited in all treatment groups, but IL-6 was inhibited only in the heat-sterilized lactic acid bacteria group (P<0.05). While measuring the changes in the amount of ethanol and acetaldehyde in the blood before and after ethanol administration, it was observed that the heat-killed lactic acid bacteria group effectively decreased after ethanol administration (P<0.001). In addition, it was confirmed that alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities were significantly increased in the heat-killed lactic acid bacteria group (P<0.001). Therefore, it was observed that heat-treated and sterilized lactic acid bacteria like live bacteria had a significant effect on acute alcoholic liver disease.
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KEYWORD
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alcohol-induced liver injury, ALDH, ADH, cytokine, heat treated lactic acid bacteria
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